Malaria, a tropical disease caused by Plasmodium parasites and spread by the bites of
infected female Anopheles mosquitoes, remains a major public health issue. Mosquito
repellents are used as a control measure.Existing ...
Polycystic Ovary Syndrome (PCOS) is an endocrine disorder with a global prevalence of 5-10%
among women of reproductive age. Women with PCOS have a 2.7-fold increased risk of developing
ovarian and cervical cancers. ...
Alstonia boonei (AB) and Alstonia congensis (AC), belonging to the family Apocynaceae are different but
closely related species, indigenous to Africa. The two plants possess varied biological activities including ...
Acetylcholinesterase (AChE) and Prolyl endopeptidases (PEP) are involved in the catalytic hydrolysis of acetylcholine and cleavage of neuropeptides influencing the activity of the brain, leading to some symptoms of Alzheimer’s ...
Sickle Cell Disease (SCD) affects primarily black populations. There are few drugs
available for the management of SCD with deleterious side effects complicating the
condition. Although many plants including Cassia ...
Reliance on imported pharmaceutical excipients has led to increased cost of finished products, necessitating the development of local excipients. Natural polymers have been used extensively as matrix systems for controlled ...
Cancer is the second leading cause of death globally. Several chemotherapeutic agents
used for the treatment of cancer have many side effects. This necessitated a search for
new potent chemotherapeutic agents with high ...
Peptic ulcer is a gastrointestinal disorder affecting about four million people globally. Some
currently used anti-ulcer drugs have side effects such as central nervous system disorder and
depression. This necessitated ...
Infant mortality, particularly in developing countries; remains a concern and one of its
major causes is diarrhoea. Human breast milk and faeces contain lactic acid bacteria
(LAB), which could have probiotic potential. ...
The search for new bioactive compounds from the wild often leads to conservation issues.
Plant tissue culture, a less destructive source of plant materials is a priority technique.
There is paucity of studies on ...
Medicinal plants are rich sources of antimalarial compounds. Combretaceae family is known from ethnobotanical survey to possess broad spectrum of activities against different diseases including malaria. The increasing trend ...
The incidence of multi-drug resistant cancer cells and the adverse effects associated with available chemotherapy have necessitated the search for new drug candidates. Several traditional healers in Africa utilise plants ...
The gut microbiota plays an important role in health and its negative alteration can lead to
different pathologies. Different factors which include birthing methods, diet and antibiotic
treatment contribute to infant ...
The incidence of multi-drug resistant cancer cells and the adverse effects associated with available chemotherapy have necessitated the search for new drug candidates. Several traditional healers in Africa utilise plants ...
Gastric ulcer results from persistent erosions and damage of the stomach wall. Ethnomedicinalsurvey revealed two plants, Securidaca longepedunculata(Polygalaceae, SL) and Luffa cylindrica (Cucurbitaceae, LC) among others ...
Salmonella is an important cause of foodborne zoonosis with significant public and animal health burden.Current interventions targeted at mitigatingSalmonella carriage in livestock include antibiotic use, which selects for ...
Mucoadhesive drug delivery systems are designed to prolong drug retention, thus offering advantages over conventional dosages through reduced dosage regimen and improved patient compliance. Natural polymers have gained ...
Extended Spectrum β-Lactamase (ESBL) is an enzyme capable of hydrolysing wide range of extended spectrum β-lactam antibiotics leading to antibiotic resistance. In Nigeria, there is a dearth of information on the genetic ...
Malaria is the second leading cause of death from infectious diseases in Africa. The
global burden of malaria is increasing due to drug-resistant parasites and insecticideresistant
mosquitoes. Meliaceae has been known ...
Clinically important herb-drug interactions have been reported for several herbs including herbal beverages. However, studies investigating interaction potentials of widely consumed aqueous beverage of Hibiscus sabdariffa ...