Hepatocellular and colonic damage are fatal outcomes arising from liver and colon toxicity.
Modulation of mitochondrial-mediated cell death is a strategy in these diseases management. The
use of synthetic drugs in the ...
Pancreatic Ductal Adenocarcinoma (PDA) and Hepatocellular Carcinoma (HCC) are
among the deadliest cancer types worldwide that are associated with arsenic intoxication.
Current drugs used in cancer management show a lot ...
Breast cancer (BC) remains a disease with high morbidity and mortality. In Nigeria,
BC represents about 23% of all cancer cases. Currently available chemotherapeutic
interventions are associated with significant adverse ...
The application of cerium oxide nanoparticle or nanoceria (CeO2NPs) in biomedical
sciences as an antioxidant agent has gained prominence in recent times. Further
medical application of CeO2NPs is still evolving. However, ...
Diabetes mellitus (DM), a metabolic disease, is becoming more prevalent globally. Solanum
macrocarpon (Linn.) is traditionally used in the treatment of DM but there is paucity of
information on the scientific evaluation ...
Arsenic, a class 1 carcinogen, is a major contaminant in drinking water globally. When
ingested by humans and animals, it contributes to tissue damage through the mechanisms
of oxidative stress and inflammation. Search ...
The opening of the mitochondrial Permeability Transition (mPT) pore is an important event
in mitochondrial-mediated cell death. Plumbagin, the active principle in Plumbago zeylanica,
induces cell death in rapidly ...
Striga hermonthica (SH) is a parasitic weed that attacks and significantly reduces the
yield of maize in Africa. The genetic interactions responsible for resistance or
susceptibility of hosts to the parasite and the ...
Benign ProstaticHyperplasia (BpH) is a progressive age-related disease. Currentdrugs used in the management of BpH have limited efficacy and many adverse effects, necessitating a continuous search for better options. Methyl ...
Ulcerative colitis (UC), a multifactorial inflammatory bowel disorder, is on the increase globally and a major risk factor for colorectal cancer. Existing drugs for treatment of UC have adverse effects, hence current ...
The opening of the Mitochondrial Membrane Permeability Transition (MMPT) pore causes cytochrome C release (CCR) which is a point of no return for apoptosis to take place. Some medicinal plants are known to induce MMPT ...
A major feature of Type 2 Diabetes Mellitus (T2DM) is tissue wastage, arising from excessive apoptosis. Excessive apoptosis could be a function of mitochondrial disorders in T2DM. Antioxidants, such as quercetin and Vitamin ...
The mitochondria have become an important component of apoptosis execution machinery. Mitochondrial Permeability Transition (mPT) pore opening constitutes the point of no return for apoptosis to take place when cytochrome ...
Diabetes mellitus (DM) and Benign prostatic hyperplasia (BPH) is a comorbidity of elderly men and is associated with complications such as infertility. Male infertility caused by this comorbidity has also been linked to ...
Okra (Abelmoschus esculentus) is a commonly consumed vegetable and useful in ethnomedicine
for the management of Diabetes mellitus. Bioregulators such as indole acetic acid (IAA) and
salicylic acid (SA) play important ...
The Mitochondrial Permeability Transition (mPT) pore opening is a calcium-dependent process resulting from an increased permeability of the mitochondrial membrane. This mPT is a major factor which promotes apoptosis. ...
Adriamycin, a widely used anti-cancer drug, induces nephrotoxicity and genotoxicity in experimental animals through generation of free radicals. Phenolic phytochemicals in guava leaves possess antioxidant properties. Hence, ...