Ulcerative colitis (UC), a multifactorial inflammatory bowel disorder, is on the increase globally and a major risk factor for colorectal cancer. Existing drugs for treatment of UC have adverse effects, hence current ...

The application of cerium oxide nanoparticle or nanoceria (CeO2NPs) in biomedical sciences as an antioxidant agent has gained prominence in recent times. Further medical application of CeO2NPs is still evolving. However, ...

Pancreatic Ductal Adenocarcinoma (PDA) and Hepatocellular Carcinoma (HCC) are among the deadliest cancer types worldwide that are associated with arsenic intoxication. Current drugs used in cancer management show a lot ...

Benign ProstaticHyperplasia (BpH) is a progressive age-related disease. Currentdrugs used in the management of BpH have limited efficacy and many adverse effects, necessitating a continuous search for better options. Methyl ...

Striga hermonthica (SH) is a parasitic weed that attacks and significantly reduces the yield of maize in Africa. The genetic interactions responsible for resistance or susceptibility of hosts to the parasite and the ...

Hepatocellular and colonic damage are fatal outcomes arising from liver and colon toxicity. Modulation of mitochondrial-mediated cell death is a strategy in these diseases management. The use of synthetic drugs in the ...

A major feature of Type 2 Diabetes Mellitus (T2DM) is tissue wastage, arising from excessive apoptosis. Excessive apoptosis could be a function of mitochondrial disorders in T2DM. Antioxidants, such as quercetin and Vitamin ...

The opening of the mitochondrial Permeability Transition (mPT) pore is an important event in mitochondrial-mediated cell death. Plumbagin, the active principle in Plumbago zeylanica, induces cell death in rapidly ...

Diabetes mellitus (DM) and Benign prostatic hyperplasia (BPH) is a comorbidity of elderly men and is associated with complications such as infertility. Male infertility caused by this comorbidity has also been linked to ...